Table 2.
Microbial Pathways Significantly Correlated With Disease Severity
| Pathway | Subclass | Coefficient | FDR- corrected P value | |
|---|---|---|---|---|
| PWY-5177: glutaryl-CoA degradation | Glutaryl-CoA degradation | -267.0167 | .0143 | Negative correlation with disease severity |
| PWY-3001: superpathway of L-isoleucine biosynthesis I | L-isoleucine biosynthesis | -557.1294 | .0387 | |
| TRNA-CHARGING-PWY: tRNA charging | Aminoacyl-tRNA Charging | -602.3432 | .0387 | |
| PWY-5103: L-isoleucine biosynthesis III | L-isoleucine biosynthesis | -654.6095 | .0387 | |
| BRANCHED-CHAIN-AA-SYN-PWY: superpathway of branched amino acid biosynthesis | Branched amino acid biosynthesis | -647.6653 | .0387 | |
| PWY-6122: 5-aminoimidazole ribonucleotide biosynthesis II | Purine nucleotide biosynthesis | -849.5535 | .0429 | |
| PWY-6277: superpathway of 5-aminoimidazole ribonucleotide biosynthesis | Purine nucleotide biosynthesis | -849.5535 | .0429 | |
| GALACTUROCAT-PWY: D-galacturonate degradation I | Sugar derivative degradation | -236.7136 | .0611 | |
| GALACT-GLUCUROCAT-PWY: superpathway of hexuronide and hexuronate degradation | Sugar derivative degradation | -204.1731 | .0885 | |
| GLUCUROCAT-PWY: superpathway of β-D-glucuronosides degradation | Sugar derivative degradation | -199.9632 | .0885 | |
| PWY-6507: 4-deoxy-L-threo-hex-4-enopyranuronate degradation | Sugar derivative degradation | -174.8413 | .1631 | |
| PWY-1269: CMP-3-deoxy-D-manno-octulosonate biosynthesis I | Sugar nucleotide biosynthesis | 727.2037 | .0043 | Positive correlation with disease severity |
| PWY-7220: adenosine deoxyribonucleotides de novo biosynthesis II | Purine nucleotide biosynthesis | 757.6133 | .0043 | |
| PWY-7222: guanosine deoxyribonucleotides de novo biosynthesis II | Purine nucleotide biosynthesis | 757.6133 | .0043 | |
| PWY-4984: urea cycle | Nitrogen compound metabolism | 337.4701 | .0043 | |
| HEMESYN2-PWY: heme biosynthesis II (anaerobic) | Heme biosynthesis | 519.5936 | .0043 | |
| PWY-6125: superpathway of guanosine nucleotides de novo biosynthesis II | Purine nucleotide biosynthesis | 818.4742 | .0048 | |
| PWY66-409: superpathway of purine nucleotide salvage | Purine nucleotide biosynthesis | 476.2132 | .0170 | |
| PWY-6471: peptidoglycan biosynthesis IV (Enterococcus faecium) | Peptidoglycan biosynthesis | 205.5374 | .0515 |
NOTE. The correlations between pathways and disease severity were determined using MaAsLin2, adjusting for age, gender, and comorbidities. Only the pathways with FDR-corrected P value <0.2 were shown.