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. 2021 Oct 7;12:700718. doi: 10.3389/fmicb.2021.700718

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Copyright © 2021 Zhang, Li, Chen and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Post-FMT and pre-FMT fecal SCFA concentrations of 18 patients were compared using paired-samples Wilcoxon tests. Butyric acid concentrations increased after FMT but not significantly. (B) Post-FMT and pre-FMT serum inflammatory factors of 18 patients were compared using paired-samples Wilcoxon tests. IL-8 levels decreased significantly after FMT. (C,D) Spearman correlation analysis of pre-FMT and post-FMT clinical symptoms, fecal microbiotas, SCFAs, and serum inflammatory factors of 18 patients revealed that IL-4, IL-8, and some SCFAs (especially butyric acid) were significantly correlated with some bacterial changes. Only IL-8 and butyric acid were correlated with clinical symptoms (“*” represents 0.01 ≤ p < 0.05; “**” represents 0.001 ≤ p < 0.01).