Table 2.
Logistic regression analysis showing the association of variables with MVI presence in the training set.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (year) | 1.03 (0.99–1.06) | 0.116 | ||
| Sex, Female vs. Male | 0.96 (0.39–2.40) | 0.923 | ||
| AFP level (ng/ml) | ||||
| <20 | [Reference] | |||
| 20–400 | 1.68 (0.74–3.85) | 0.216 | ||
| >400 | 3.06 (1.40–6.93) | 0.006 | ||
| ALT level (IU/L),<40 vs.>40 | 0.69 (0.36–1.33) | 0.256 | ||
| AST level (IU/L),<35 vs.>35 | 0.83 (0.43–1.61) | 0.588 | ||
| ALB level (g/L),>40 vs.<40 | 0.55 (0.20–1.49) | 0.239 | ||
| T-BIL level (μmol/l),<20 vs.>20 | 0.54 (0.25–1.14) | 0.105 | ||
| ALP level (U/L),<135 vs.>135 | 0.92 (0.34–2.54) | 0.864 | ||
| GGT level (U/L),<45 vs.>45 | 1.18 (0.61–2.30) | 0.621 | ||
| PT (s),<14 vs.>14 | 1.49 (0.14–32.57) | 0.745 | ||
| MR features | ||||
| Tumour size (cm) | 1.02 (1.01–1.04) | 0.005 | ||
| Tumour growth type | ||||
| Smooth regular nodule growth | [Reference] | [Reference] | ||
| Focal extranodular growth | 3.73 (0.52–76.26) | 0.254 | 4.15 (0.53–89.11) | 0.235 |
| Multinodular confluent growth | 6.28 (1.02–121.45) | 0.096 | 4.82 (0.71–97.25) | 0.168 |
| Infiltrative growth | 29.17 (4.60–573.18) | 0.003 | 15.73 (2.21–322.58) | 0.017 |
| Capsule | ||||
| Complete | [Reference] | |||
| Incomplete | 3.72 (1.50–9.81) | 0.006 | ||
| Absent | 3.56 (1.37–9.78) | 0.011 | ||
| Enhancement pattern, | 0.88 (0.33–2.29) | 0.803 | ||
| Untypical vs. Typical | ||||
| Peritumoral enhancement, | 6.94 (3.39–14.78) | <0.001 | 4.38 (1.98–9.95) | 0.003 |
| Absent vs. Present | ||||
| HBP signal intensity, | 2.26 (0.88–6.15) | 0.096 | ||
| Hypointensity vs. Other | ||||
| Peritumoral hypointensity on HBP, | 4.87 (2.42–10.20) | <0.001 | ||
| Absent vs. Present | ||||
| Intratumoral vasculature, | 2.37 (1.21–4.78) | 0.014 | ||
| Absent vs. Present | ||||
| Intratumoral fat, | 0.63 (0.29–1.34) | 0.227 | ||
| Absent vs. Present | ||||
| Intratumoral necrosis, | 2.73 (1.39–5.51) | 0.004 | ||
| Absent vs. Present | ||||
| Intratumoral haemorrhage, | 1.98 (0.93–4.43) | 0.085 | ||
| Absent vs. Present | ||||
MVI, microvascular invasion; OR, odds ratio; AFP, α-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransaminase; ALB, albumin; T-BIL, total bilirubin; ALP, alkaline phosphatase; GGT, γ-glutamyltransferase; PT, prothrombin time.