TABLE 3.

Main effects and interactions emerged from the analyses.

Brain Region	Side	Cluster Size (voxels)	Cluster-Level pFWE	z Score	Talairach Coordinates
					x	y	z
Main Effects
High WMH Load > Low WMH Load – Salience Network
Precentral Gyrus (BA4)	R	110	0.020	4.58	36	−26	64
Postcentral Gyrus (BA2)	R			3.41	30	−35	68
Inferior Frontal Gyrus (BA47)	R	102	0.029	4.04	38	26	−18
Non-Amnestic > Amnestic – Salience Network
Medial Frontal Gyrus (BA11)	L	134	0.007	4.63	−10	63	−15
Non-Amnestic > Amnestic – Default-Mode Network
Middle Frontal Gyrus (BA8)	L	99	0.026	4.33	−48	12	38
Inferior Frontal Gyrus (BA45)	L	151	0.002	3.89	−57	11	18
Inferior Frontal Gyrus (BA45)	L			3.79	−48	16	14
Inferior Frontal Gyrus (BA44)	L			3.74	−57	16	12
Non-Amnestic > Amnestic – Left Frontoparietal Network
Precuneus (BA7)	L	94	0.028	4.20	−12	−50	54
Precuneus (BA7)	L			3.83	−6	−57	62
Precuneus (BA7)	L			3.18	−20	−46	56
Interaction Effects
Low WMH Load Advantage Stronger in Amnestic –
Salience Network
Insula (BA13)	R	109	0.021	4.16	42	−16	1
Insula (BA13)	R			3.76	38	−25	3
Low WMH Load Advantage Stronger in Amnestic –
Left Frontoparietal Network
Insula (BA13)	R	131	0.008	4.57	30	17	−8
Middle Frontal Gyrus (BA9)	R			4.43	28	42	33
Superior Frontal Gyrus (BA9)	R			3.84	24	54	32
Superior Frontal Gyrus (BA10)	R			3.66	26	54	23
Low WMH Load Advantage Stronger in Non-Amnestic –
Left Frontoparietal Network
Parahippocampal Gyrus (BA35)	L	124	0.011	4.29	36	−26	64
Uncus	L			1.03	30	−35	68
Parahippocampal Gyrus (BA35)	L			3.65	38	26	−18

BA, Brodmann area; FWE, family-wise error; L, left; R, right; WMHs, white-matter hyperintensities.