Table 1.
Predictive measures C-index and AUC of the topmost genetic and lifestyle factors in association with colorectal cancer risk.
| African American women | Hispanic American women | |||||
|---|---|---|---|---|---|---|
| Type of variable | Topmost influential variables* | C-index | AUC (95% CI) | Topmost influential variables* | C-index | AUC (95% CI) |
| SNP | PCSK1 rs9285019 | 0.4715 | 0.561 (0.491 – 0.631) | IFT172 rs780104 | 0.7064 | 0.798 (0.688 – 0.907) |
| GCKR rs6753534 | 0.8175 | |||||
| NRBP1 rs704791 | 0.8048 | |||||
| Lifestyle factors | Years as a regular smoker | 0.5023 | 0.627 (0.566 – 0.689) | % calories from MFA/day | 0.5979 | 0.675 (0.526 – 0.823) |
| % calories from PFA/day | 0.5356 | Number of cigarettes/day | 0.5245 | |||
| Age at menopause | 0.5486 | Age at menopause | 0.5655 | |||
| Age at enrollment | 0.6014 | % calories from SFA/day | 0.5836 | |||
| Duration of OC use | 0.6223 | % calories from PFA/day | 0.5896 | |||
| Dietary total sugars | 0.6301 | Dietary vitamin K | 0.5721 | |||
|
SNP +
Lifestyle factors |
1 SNP + 6 lifestyle factors |
0.647 (0.586 – 0.708) | 3 SNPs + 6 lifestyle factors |
0.830 (0.721 – 0.939) | ||
AUC, area under the receiver operating characteristic curve; CI, confidence interval; C-index, concordance index; MFA, monounsaturated fatty acid; OC, oral contraceptive; PFA, polyunsaturated fatty acid; SFA, saturated fatty acid; SNP, single-nucleotide polymorphism.
*Topmost predictive variables were selected on the basis of random survival forest analysis with a multimodal approach.