Table 2.
Presenting Clinical Symptoms, Laboratory, Radiologic Results and Concomitant OI Diagnosis of TE Patients at Index Hospitalization.
| Clinical presentation | Proportion | % |
|---|---|---|
| Length of symptoms prior to presentation in weeks, median (range) | 1.5 (0-12) | |
| Headache | 22/34 | 67.6% |
| Focal neurologic symptoms | 24/38 | 63.2% |
| Cognitive impairment | 14/33 | 42.4% |
| Seizures | 13/36 | 36.1% |
| Fever | 12/35 | 35.3% |
| Altered consciousness | 10/37 | 27% |
| Meningeal symptoms | 0/36 | 0% |
| Toxoplasmosis IgG+ | 36/37 | 97.3% |
| Lumbar Puncture performed | 28/38 | 73.7% |
| Toxoplasmosis PCR+ | 8/26 | 30.8% |
| CSF pleocytosis (>10 cells) | 8/28 | 28.6% |
| Abnormal protein (>45 mg/dl) | 13/28 | 46.4% |
| Abnormal glucose (<40 mg/dl) | 2/28 | 7.1% |
| Number of MRI lesions | ||
| 1 | 13/38 | 34.2% |
| 2-5 | 9/38 | 23.7% |
| >5 | 16/38 | 42.1% |
| Contrast Enhancement on MRI | 38/38 | 100% |
| Mass Effect | 24/38 | 63.2% |
| Midline Shift | 12/38 | 31.6% |
| Need for Neurosurgical Intervention | 5/36 | 13.9% |
| Admission to intensive care unit | 14/38 | 36.8% |
| Concomitant opportunistic infections diagnosed during hospitalization | 14/37 | 37.8% |
| candidiasis | 7/37 | 18.9% |
| cytomegalovirus (CMV) disease | 6/37 | 16.2% |
| bacterial infection | 2/37 | 5.4% |
| non-tuberculosis mycobacteria, disseminated or extrapulmonary | 2/37 | 5.4% |
| herpes simplex virus, bronchitis, pneumonitis, esophagitis | 2/37 | 5.4% |
| disseminated histoplasmosis | 1/37 | 2.7% |
| central nervous system lymphoma | 1/37 | 2.7% |
| HIV wasting syndrome | 1/37 | 2.7% |