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. 2021 Oct 7;15:759574. doi: 10.3389/fnbeh.2021.759574

FIGURE 3.

FIGURE 3

Comparison between the P22–26 and P32–36 mouse cohorts within C57BL/6N, DBA/2, and FVB/N strains. (A) In the tail suspension test, P32 C57BL/6N and P32 FVB/N mice showed a significantly increased immobility duration and decreased latency to first immobility compared to P22 C57BL/6N and P22 FVB/N mice, respectively. (B) In the sucrose preference test, FVB/N mice showed an increased sucrose preference index in older compared to younger mice with no effect of age on C57BL/6N and DBA/2 strains. (C) In the forced swim test, P36 C57BL/6N and P36 FVB/N mice showed a significantly increased immobility duration compared to P26 C57BL/6N and P26 FVB/N mice, respectively. For the latency to the first immobility, only P36 FVB/N mice showed a significantly decreased latency to the first immobility compared to P26 mice. For the total traveled distance, all three strains showed a decreased traveled distance in older compared to a younger age. Two-way ANOVA followed by Tukey post hoc test,*p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. Error bars indicate the standard error of the mean (SEM).