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. 2021 Oct 7;15:747067. doi: 10.3389/fnins.2021.747067

FIGURE 2.

FIGURE 2

CDKN2A gene expression (using primers for p16INK4A and p14ARF) is significantly increased in elderly ascending and descending colon. Panel (A) compares the elderly and adult samples from both regions, relative to expression in adult ascending colon, which has been normalized to 1. ATP5B and GAPDH were used as endogenous controls. Results represent fold-change differences. Adult samples (25–60 years old) are represented by •. Elderly samples (70 + years old) are represented by ■. Bars indicate data mean. *P < 0.05. Student’s t-test used to calculate P value for each gene, comparing between age groups. Panel (B) shows the correlations between CDKN2A gene expression and increasing age (years). P values for linear regression lines are, respectively, 0.0087 and 0.0063 for ascending and descending colon (calculated using Prism).