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. 2021 Oct 19;41(10):BSR20211338. doi: 10.1042/BSR20211338

Table 3. Association between genotypes of selected SNPs and GDM susceptibility.

Gene Genotype Case Control P 1 Crude OR (95% CI) P 2 Adjusted OR (95% CI) P 3
RXR-α rs4842194
GG 235 327 0.326 1 1
GA 263 333 1.10 (0.87–1.39) 0.427 1.05 (0.82–1.35) 0.68
AA 75 80 1.31 (0.91–1.86) 0.144 1.31 (0.90–1.91) 0.164
AA/GA 338 413 0.249 1.14 (0.91–1.42) 0.249 1.10 (0.87–1.39) 0.418
GG/GA 498 660 0.227 1 1
AA 75 80 1.24 (0.89–1.74) 0.205 1.27 (0.89–1.82) 0.183
RXR-γ rs100537
AA 48 55 0.199 1 1
AG 257 302 0.98 (0.64–1.49) 0.907 0.87 (0.56–1.36) 0.546
GG 268 383 0.80 (0.53–1.22) 0.3 0.78 (0.50–1.21) 0.268
GG/AG 525 685 0.536 0.88 (0.59–1.32) 0.528 0.82 (0.54–1.26) 0.364
AA/AG 305 357 0.075 1
GG 268 383 0.82 (0.66–1.02) 0.073 0.88 (0.70–1.10) 0.259
rs2134095
TT 158 219 0.004 1 1
TC 324 357 1.26 (0.98–1.62) 0.076 1.32 (1.01–1.73) 0.043
CC 91 164 0.77 (0.55–1.07) 0.117 0.85 (0.60–1.20) 0.363
CC/TC 415 521 0.425 1.10 (0.87–1.41) 0.422 1.17 (0.91–1.52) 0.221
TT/TC 482 576 0.003 1
  CC 91 164   0.72 (0.580.89) 0.003 0.71 (0.560.90) 0.004

The significance level after Bonferroni's correction for multiple testing is 0.017. Bold values indicate that the difference is statistically significant.

1

Two-sided χ2 test for genotypes’ distributions between cases and controls.

2

Unconditional logistic regression analysis.

3

Adjusted for age, pre-BMI in logistic regression models.