Table 3. Association between genotypes of selected SNPs and GDM susceptibility.
Gene | Genotype | Case | Control | P 1 | Crude OR (95% CI) | P 2 | Adjusted OR (95% CI) | P 3 |
---|---|---|---|---|---|---|---|---|
RXR-α | rs4842194 | |||||||
GG | 235 | 327 | 0.326 | 1 | 1 | |||
GA | 263 | 333 | 1.10 (0.87–1.39) | 0.427 | 1.05 (0.82–1.35) | 0.68 | ||
AA | 75 | 80 | 1.31 (0.91–1.86) | 0.144 | 1.31 (0.90–1.91) | 0.164 | ||
AA/GA | 338 | 413 | 0.249 | 1.14 (0.91–1.42) | 0.249 | 1.10 (0.87–1.39) | 0.418 | |
GG/GA | 498 | 660 | 0.227 | 1 | 1 | |||
AA | 75 | 80 | 1.24 (0.89–1.74) | 0.205 | 1.27 (0.89–1.82) | 0.183 | ||
RXR-γ | rs100537 | |||||||
AA | 48 | 55 | 0.199 | 1 | 1 | |||
AG | 257 | 302 | 0.98 (0.64–1.49) | 0.907 | 0.87 (0.56–1.36) | 0.546 | ||
GG | 268 | 383 | 0.80 (0.53–1.22) | 0.3 | 0.78 (0.50–1.21) | 0.268 | ||
GG/AG | 525 | 685 | 0.536 | 0.88 (0.59–1.32) | 0.528 | 0.82 (0.54–1.26) | 0.364 | |
AA/AG | 305 | 357 | 0.075 | 1 | ||||
GG | 268 | 383 | 0.82 (0.66–1.02) | 0.073 | 0.88 (0.70–1.10) | 0.259 | ||
rs2134095 | ||||||||
TT | 158 | 219 | 0.004 | 1 | 1 | |||
TC | 324 | 357 | 1.26 (0.98–1.62) | 0.076 | 1.32 (1.01–1.73) | 0.043 | ||
CC | 91 | 164 | 0.77 (0.55–1.07) | 0.117 | 0.85 (0.60–1.20) | 0.363 | ||
CC/TC | 415 | 521 | 0.425 | 1.10 (0.87–1.41) | 0.422 | 1.17 (0.91–1.52) | 0.221 | |
TT/TC | 482 | 576 | 0.003 | 1 | ||||
CC | 91 | 164 | 0.72 (0.58–0.89) | 0.003 | 0.71 (0.56–0.90) | 0.004 |
The significance level after Bonferroni's correction for multiple testing is 0.017. Bold values indicate that the difference is statistically significant.
Two-sided χ2 test for genotypes’ distributions between cases and controls.
Unconditional logistic regression analysis.
Adjusted for age, pre-BMI in logistic regression models.