Table 2.

Summary of all discordant reads

Specimen type	Reference diagnosis	Observed diagnosis	Modality (OM/WSI) and discrepant pathologist	Discordance category
Lymph node	Metastatic lymph node	Reactive LN	P1-OM P2-WSI	Major
Lymph node	Reactive LN	Metastatic LN	P2-WSI	Major
Lymph node	Reactive LN	Metastatic LN	P2-OM	Major
Primary diagnosis	Breast (nipple under shave)-benign breast disease Ductal hyperplasia	DCIS	P1-OM and WSI P2-OM and WSI P3-WSI P4-OM and WSI	Major
Primary diagnosis	Thyroid-papillary thyroid carcinoma	Adenomatous thyroid lesion with goitre Benign thyroid lesion	P2-WSI P3-OM and WSI	Major
Primary diagnosis	Oesophagus-squamous cell carcinoma	Hyperplastic and inflamed squamous mucosa	P1-WSI	Major
Margin	Tongue base-involved by squamous cell carcinoma	Free of tumour	P1-OM P2-OM P4-OM	Major
Margin	Larynx-dysplasia	Free of dysplasia/tumour	P2-OM &WSI P4-OM	Major
Primary diagnosis	Thyroid-Papillary thyroid carcinoma	Follicular carcinoma of thyroid	P4-WSI	Minor
Primary diagnosis	Frozen diagnosis:  Salivary gland tumor with secretory morphology  Metastatic adenocarcinoma Final HPR: Secretory carcinoma of salivary gland	Papillary thyroid carcinoma metastasis	P1-WSI	Minor
Primary diagnosis	Esophagus: Squamous cell carcinoma (microinvasive)	Dysplastic and inflamed squamous mucosa	P2-OM and WSI P3-WSI	Minor
Primary diagnosis	Gall bladder-papillary adenocarcinoma	Intracystic papillary proliferation	P2-OM and WSI	Minor
Primary diagnosis	Ovary: Benign serous cystadenoma	Borderline ovarian tumor	P1-WSI P2-OM and WSI	Minor
Primary diagnosis	Ovary: Sex cord tumor favor granulosa cell tumor	Adenocarcinoma	P1-OM P4-WSI	Minor

LN: Lymph node, OM: Optical microscopy, WSI: Whole-slide imaging, P1: Pathologist 1, P2: Pathologist 2, P1-P3: Pathologist 3, P4-P1: Pathologist 4, DCIS: Ductal carcinoma in situ