Table 4.

Comparison of the current study with the major published whole-slide imaging studies for frozen section diagnosis in literature

Reference, year	Number of cases	Scanner	Diagnostic accuracy (%)	Observer variability	Cohen’s kappa (K)	Mean scanning time (range)	Mean reporting time (range)
Tsuchihashi et al., 2008	15	Vassalo	100	N/S	N/P	10 min (N/S)	5 min (N/S)
Slodkowska et al., 2009	33	Aperio scan scope	100	Inter-observer	N/P	N/S (2-7 min)	N/S (1-2 min)
Fallon et al., 2010	52	Mirax Desk	96	Inter-observer	N/P	9 (1-20 min)	N/S (3-5 min)
Ramey et al., 2011	67	Aperio scan scope	89	Inter-observer	0.85	3 (1-9 min)	1 (30 s-13 min)
Gould et al., 2012	30	Nanozoomer 2.0	96.7	Inter-observer	N/P	N/S	N/S
Perron et al., 2014	104	Nanozoomer 2.0	98.1	Inter-observer	N/P	5 min (1-25 min)	1 min (1-10 min)
Ribback et al., 2014	1204	Mirax Desk	98.6	Intra-observer	N/P	11 min (3-19 min)
Bauer et al., 2015	70	Aperio CS2	95.7	Intra-observer	N/P	N/S	N/S
Yu et al., 2017	100	Aperio AT2	1:61 2:74 3:87 4:75	Inter-observer	N/P	N/S	N/S
Cima et al.,2018	125	Navigo	97	Intra-observer	0.96	12 min	3 min
Present study 2020	60	Grundium Ocus®	95	Inter-observer and intra-observer	Inter: 0.915 Intra: 0.905	H and E: 1 min 47 s TOLB: 1 min 46 s	1 min 8 s

N/P: Not performed, N/S: Not specified, TOLB: Toluidine blue