Figure 6.

Silencing HSP90. (A, B) Western blots showing optimization of HSP90 silencing. WT and del4 cholangiocytes were grown on Matrigel and monitored for 1 week. (C, D) Cyst growth is inhibited by silencing HSP90. All data are expressed as mean ± SEM. P values were determined by Student’s t test. Number of cysts represented in the figure (dots) are from individual cysts. Number of Western blot experiments represented in the figure (dots) are from independent 10-cm dishes of cultured cells. ∗∗∗∗P < .0001. siRNA, small interfering RNA.