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. 2021 Oct 19;8(6):e1094. doi: 10.1212/NXI.0000000000001094

Figure 2. Age-Related Changes in the CD8 T-Cell Compartment in Patients With MS and HDs.

Figure 2

Composition of the CD8 T-cell compartment in the peripheral blood of young (≤50 years) and old (>50 years) patients with MS (young: n = 40, old: n = 38) and HDs (young: n = 20, old: n = 20). Demographic data of study subjects are depicted in eTable 1 (A–D, links.lww.com/NXI/A620). Proportions of naive (A), memory (B), effector memory (C), and central memory (D) CD8 T cells. Data are displayed as boxplots of the median and the 25th and 75th percentile ± interquartile range. Statistical analysis was conducted by the 2-tailed Mann-Whitney test. Differences were considered statistically significant with the following P values: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. CM = central memory; EM = effector memory; HD = healthy donor.