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. 2021 Aug 26;8(20):2101526. doi: 10.1002/advs.202101526

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© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Scheme 1 — Illustration of Ma@(MnO₂+FTY) nanoparticles formation and salvation of damaged neurons in ischemic brain. a) Scheme of the preparation process of Ma@(MnO₂+FTY) nanoparticles. b) Illustration of Ma@(MnO₂+FTY) therapy for the rescue of ischemic penumbra. Coating with macrophage cell membrane increased the accumulation of Ma@(MnO₂+FTY) nanoparticles in the damaged brain. Ma@(MnO₂+FTY) could protect damaged neurons by consuming ROS, generating O₂ and regulating proinflammatory microenvironment through promoting the phenotypic transition of microglia.