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Illustration of Rapamycin-SIRT2 dependent FKBP12-mTOR inactivation in innate immunity
FKBP12 can be acetylated in cells in the presence of nutrients. Rapamycin recruits SIRT2 but not HDAC1 to deacetylate FKBP12, which can then associate with mTOR. Acetyl-FKBP12 however associates with acetyl-Rheb to form a moderate mTOR activator. mTOR activated IRF3 undergoes nuclear translocation and gene activation leading to anti-viral response, which can be restricted by rapamycin treatment.
