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Model of fatty acylated EETI-II cellular uptake
Fatty acylated EETI-II can enter cells through endocytosis and macropinocytosis. Importantly, a pool of fatty acylated peptides, primarily with C14 and C16 modifications, is found on the plasma membrane and in the cytosol. Although the majority of fatty acylated EETI-II localizes in the lumen of endosomes/lysosomes, a fraction can be detected on the ER, Golgi and mitochondrial membranes. The cartoon was created with BioRender.com.
