Table 1. Effects of MORE on the Physiological Changes in Mice with HFD/STZ-Induced Diabetesa.
| group | body weight (g) | calorie intake (kcal) | serum glucose (mg/dL) | serum insulin (μU/mL) | HOMA-IR index |
|---|---|---|---|---|---|
| Nor | 28.00 ± 1.00 | 74.40 ± 3.10 | 94.60 ± 16.89 | 4.78 ± 0.42 | 0.96 ± 0.09 |
| control | 32.33 ± 2.08### | 99.56 ± 5.24### | 516.20 ± 33.10### | 3.19 ± 0.38## | 3.31 ± 0.31### |
| MORE100 | 28.67 ± 2.08** | 85.59 ± 3.02*** | 461.60 ± 35.23* | 4.11 ± 0.61 | 2.61 ± 0.47* |
| MORE200 | 28.33 ± 2.51** | 90.83 ± 8.01* | 403.40 ± 29.05*** | 4.45 ± 1.05* | 2.60 ± 0.73* |
| Met | 26.33 ± 1.52*** | 76.85 ± 8.00*** | 286.00 ± 37.58*** | 4.68 ± 1.08** | 2.43 ± 0.67** |
a
The data are expressed as the mean ± S.D. (n = 5). Nor, normal group; Control, group with HFD/STZ-induced diabetes; MORE100, mice administered 100 mg/kg MORE; mice administered 200 mg/kg MORE; and Met, group administered 250 mg/kg metformin. ##p < 0.01, ###p < 0.001 vs Nor; *p < 0.05, **p < 0.01, ***p < 0.001 vs control.