Table 5.

Evaluation of the prioritization algorithm using the 12 known AD-associated microbial metabolites among 220 microbial metabolites. A mean value of top 15.08% means that on average the 12 AD-associated metabolites ranked in the top 15.08% among the prioritized list of 216 microbial metabolites, which was significantly higher than the expected ranking of 50% based on random ranking

Input	Mean (top %)	Median (top %)	P-value
Abnormal microglial cell physiology	15.08	13.89	3.19E−07
Abnormal microglial cell morphology	15.39	11.11	1.84E−06
Microgliosis	15.63	11.11	4.16E−06
Combined	14.39	11.34	1.06E−06