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. 2021 Oct 20;19:330. doi: 10.1186/s12951-021-01076-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a Plasma concentration of DOX·HCl and SNM@DOX versus time after i.v. injection. b Time-dependent biodistributions of DOX·HCl and SNM@DOX in the main organs. c Schematic illustration of the preparation of ⁸⁹Zr SNM@DOX through multi-components self-assembly followed by radiolabelling. d PET images of the mice bearing HepG2 tumor at different time post i.v. injection of ⁸⁹Zr SNM@DOX