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a Tumor volume changes of the mice administrated with different formulations. ***p < 0.001. b Tumor inhibition rate of the mice administrated with different formulations. c H&E staining of the tumor tissues from the mice treated with PBS, SNPs, DOX·HCl, and SNM@DOX, respectively. Scale bar is 50 μm. d Blood biochemistry tests of ALP, AST, and ALT from the mice treated with different formulations. *p < 0.05, **p < 0.01
