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. 2021 Oct 7;11:704607. doi: 10.3389/fonc.2021.704607

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Copyright © 2021 Guerrisi, Russillo, Loi, Ganeshan, Ungania, Desiderio, Bruzzaniti, Falcone, Renna, Ferraresi, Caterino, Solivetti, Cognetti and Morrone

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The figure compares survival curves for baseline CT texture parameter kurtosis at fine (SSF = 2) and medium (SSF = 3) texture scales, and delta-analysis quantified Perc-ENTRO at medium and coarse scales for PFS. Patients in the good prognostic group, as identified by baseline kurtosis at fine (SSF = 2) and medium (SSF = 3) texture scales, had an improved median PFS of around 28 (A) and 13 months (B) respectively, compared to the respective poor prognostic group. Furthermore, the good prognostic group defined using Kurtosis demonstrated zero progression. Patients in the good prognostic group, as identified by Perc-ENTRO, had an improved median PFS of around 8 months (C, D) compared to the poor prognostic group.