Table 4.

(a–d) Multivariate Cox regression analysis including individual significant univariate texture parameters (selected using LASSO) and clinical variables for predicting PFS.

	Covariate	HR	CI	p-value
a.	Kurtosis (SSF = 2)	0.53	0.29–0.95	0.03
	LDH	0.27	0.06–1.26	0.09
	No. of metastatic sites	2.59	0.75–8.9	0.13
b.	Kurtosis (SSF = 3)	0.49	0.25–0.96	0.03
	LDH	0.30	0.06–1.4	0.12
	No. of metastatic sites	2.62	0.76–8.99	0.13
c.	Perc-ENTRO (SSF = 4)	1.07	1.01–1.13	0.009
	No. of met sites	3.98	1.14–13.6	0.03
	Perc-LDH	0.28	0.07–1.1	0.07
d.	Perc-ENTRO (SSF = 6)	1.07	1.02–1.13	0.005
	No. of met sites	4.10	1.19–14.1	0.02
	Perc-LDH	0.27	0.07–1.1	0.06

HR, hazard ratio; CI, confidence interval.