Table 4.
Univariable analysis of prognostic factors associated with primary and secondary endpoints
| Variables | Transient elastography | Magnetic resonance elastography | ||||||
|---|---|---|---|---|---|---|---|---|
| Primary endpoint | Secondary endpoint | Primary endpoint | Secondary endpoint | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Male | 3.29 (0.66–16.39) | 0.15 | 1.96 (0.43–8.88) | 0.39 | 3.51 (1.40–8.81) | 0.01 | 2.19 (0.84–5.68) | 0.11 |
| Age | 0.73 (0.37–1.45) | 0.37 | 1.05 (0.59–1.88) | 0.87 | 1.12 (0.79–1.58) | 0.52 | 1.27 (0.93–1.72) | 0.13 |
| LS | 1.12 (1.07–1.18) | <0.001 | 1.12 (1.08–1.17) | <0.001 | 1.65 (1.40–1.94) | <0.001 | 1.58 (1.36–1.84) | <0.001 |
| AST / ULN | 2.37 (1.54–3.65) | <0.001 | 2.12 (1.49–3.00) | <0.001 | 1.23 (1.08–1.41) | 0.002 | 1.23 (1.10–1.38) | <0.001 |
| ALP / ULN | 1.48 (1.20–1.82) | <0.001 | 1.51 (1.29–1.77) | <0.001 | 1.19 (1.10–1.28) | <0.001 | 1.19 (1.11–1.27) | <0.001 |
| Total Bilirubin | 1.76 (1.05–2.93) | 0.03 | 2.02 (1.47–2.77) | <0.001 | 1.25 (1.10–1.42) | <0.001 | 1.29 (1.18–1.42) | <0.001 |
| Albumin | 0.09 (0.02–0.42) | 0.003 | 0.09 (0.03–0.32) | <0.001 | 0.18 (0.08–0.42) | <0.001 | 0.14 (0.07–0.28) | <0.001 |
| Sodium | 1.17 (0.83–1.65) | 0.38 | 1.37 (1.01–1.86) | 0.04 | 1.00 (0.84–1.18) | 0.97 | 0.91 (0.78–1.04) | 0.16 |
| Creatinine | 1.02 (0.24–4.27) | 0.98 | 1.34 (0.66–2.70) | 0.42 | 1.01 (0.22–4.53) | 0.99 | 0.38 (0.06–2.41) | 0.31 |
| Platelet Count | 0.99 (0.94–1.00) | 0.01 | 0.99 (0.98–1.00) | 0.05 | 0.99 (0.98–0.99) | <0.001 | 0.99 (0.99–1.00) | 0.002 |
| INR | 0.84 (0.03–22.83) | 0.92 | 1.13 (0.18–6.96) | 0.90 | 1.05 (0.68–1.62) | 0.82 | 1.05 (0.74–1.51) | 0.77 |
| APRI | 5.15 (2.74–9.69) | <0.001 | 3.90 (2.38–6.40) | <0.001 | 1.31 (1.15–1.50) | <0.001 | 1.27 (1.12–1.45) | <0.001 |
| GLOBE Score | 1.96 (1.05–3.65) | 0.03 | 1.96 (1.16–3.30) | 0.01 | 1.31 (0.99–1.74) | 0.06 | 1.49 (1.16–1.91) | 0.002 |
| UDCA Responder | 0.15 (0.02–1.40) | 0.10 | 0.33 (0.07–1.47) | 0.15 | 0.26 (0.08–0.84) | 0.03 | 0.28 (0.10–0.81) | 0.02 |
Abbreviations: HR, Hazard Ratio; CI, Confidence Interval; LS, Liver Stiffness; AST, Aspartate aminotransferase; ULN, Upper Limit of Normal; ALP, Alkaline Phosphatase; INR, International Normalized Ratio; APRI, AST to Platelet Ratio Index; UDCA, Ursodeoxycholic acid.