Table 2. Baseline characteristics and details of included studies.

ALT: Alanine Transaminase; ALP: Alkaline Phosphatase; AST: Aspartate Transaminase; DILI: Drug-Induced Liver Injury; GGT: Gamma-Glutamyl Transferase; IU/L: International Unit per Liter; IV: Intravenous; K: per 1,000 persons; mg/dL: Milligrams (mg) per Deciliter; mg: Milligram; mm3: Cubic Millimeter; μmol/L: Micromoles per Liter; UK: United Kingdom; US: United States of America; U/L: Units/Liter

Study ID/Year	Study design	Country	Sample size(n)	Exposure	Outcome
Rodrıguez et al., 1999 [32]	Cohort study	UK	69,830	Oral antifungals with a background rate of 0.6 per100 000 person-month	Ketoconazole and itraconazole were the two oral antifungals associated with a marked increase of clinical acute liver injury.
Perveze et al., 2006 [33]	Case study	US	1	Oral terbinafine for three months	terbinafine-induced severe liver a case of terbinafine-induced severe liver failure
Paredes et al., 2007 [34]	Case study	US	1	Oral terbinafine for twelve weeks	aspartate aminotransferase (1282 IU/L), alanine aminotransferase (1044 IU/L), and bilirubin (5.9 mg/dL); platelet level decreased to 77 × 103/mm3
Kao et al., 2013 [35]	Cohort study	Taiwan	90,847	Ketoconazole, 12 fluconazole, eight griseofulvin, three itraconazole and two terbinafine	The incidence rates (IR) of DILI per 10k persons 31.6, 4.9, 4.3, 3.6 and 1.6 for fluconazole, ketoconazole, griseofulvin, itraconazole and terbinafine, respectively.
Chan et al., 2014 [36]	Case study	Malaysia	1	34-year-old with elevated liver enzymes due to fluconazole (IV) 200 mg stat followed by IV 100 mg daily.	ALT and total bilirubin level further rose to 2394 U/L and 94 μmol/L on day 6
Gayam et al., 2018 [37]	Case study	US	1	IV fluconazole 200 mg daily	On day 3 AST of 25kIU/L, an ALT of 6.5k IU/L, a GGT of 210 IU/L, alkaline phosphatase of 130 IU/L, a total bilirubin 2.3 mg/ dL, and a direct bilirubin 0.4 mg/ dL