ATF6 |
activating transcription factor 6 |
|
AMPK |
adenosine monophosphate activated protein kinase |
|
APC |
antigen-presenting cell |
|
BiP |
binding immunoglobulin protein |
|
CCR2 |
C-C chemokine receptor-2 |
|
CCL2 |
C-C ligand 2 |
|
JNK |
c-Jun N-terminal Kinase |
|
Clec16A |
C-type lectin domain family 16, member A |
|
CXCL10 |
C-X-C motif chemokine ligand 10 |
|
Ca2+
|
calcium |
|
GPx |
glutathione peroxidase |
|
CCL5 |
CC ligand 5 |
|
ChgA |
chromogranin-A |
|
CRISPR |
Clustered Regularly Interspaced Short Palindromic Repeat |
|
CXCR3 |
CXC receptor 3 |
|
DLK1 |
Delta-like 1 |
|
LCMV-WE |
diabetogenic lymphocytic choriomeningitis virus-WE strain |
|
E |
embryonic day |
|
ER |
endoplasmic reticulum |
|
FasL |
Fas ligand |
|
FISH |
fluorescence in situ hybridization |
|
GDM |
gestational diabetes mellitus |
|
Glut2 |
glucose transporter 2 |
|
GSIS |
glucose-stimulated insulin secretion |
|
Gad65 |
glutamic acid decarboxylase 65 |
|
GWAS |
Genome-Wide Association Study |
|
HLA |
human leukocyte antigen |
|
HIPs |
hybrid insulin peptides |
|
H2O2
|
hydrogen peroxide |
|
iPSC |
induced pluripotent stem cell |
|
iNOS |
inducible nitric oxide |
|
IRE1a |
inositol-requiring enzyme 1 alpha |
|
INS
|
INSULIN
|
|
IFNγ |
interferon gamma |
|
IL-1β |
interleukin-1 beta |
|
IP-10 |
IFNγ inducible protein 10 |
|
IAPP |
islet amyloid polypeptide |
|
LADA |
latent autoimmune diabetes in adults |
|
MHC |
major histocompatibility chain |
|
MODY |
maturity onset diabetes of the young |
|
MCP)-1 |
monotype chemoattractant protein |
|
NOD |
non-obese diabetic |
|
NFκB |
nuclear factor κB |
|
Pdx1 |
pancreatic and duodenal homeobox 1 |
|
pLNs |
pancreatic lymph nodes |
|
PAD |
peptidyl arginine deiminase |
|
PTM |
post-translational modification |
|
Pref-1 |
preadipocyte factor 1 |
|
PAK-2 |
protein activated kinase 2 |
|
PERK |
protein kinase RNA-like endoplasmic reticulum kinase |
|
RANTES |
regulated on activation, normal T cell expressed and secreted |
|
ROS |
reactive oxygen species |
|
Rnls
|
renalase |
|
SNPs |
single nucleotide polymorphisms |
|
SOD |
superoxide dismutase |
|
T1DGC |
T1D Genetics Consortium |
|
TUDCA |
tauroursdoxycholic acid |
|
TRX |
thioredoxin |
|
TXNIP |
thioredoxin interacting protein |
|
tTG2 |
tissue transglutaminase 2 |
|
TLR4 |
Toll like receptor-4 |
|
TNFα |
tumor necrosis factor alpha |
|
T1D |
Type 1 diabetes |
|
T2D |
Type 2 diabetes |
|
UPR |
unfolded protein response |
|
UCN-3 |
urocortin-3 |
|
VNTR |
variable number tandem repeat |
|
WTCCC |
Wellcome Trust Case Control Consortium |
|