Table 2.
Phenotype associations in male and female patients
| Men | Women | ||||||||
| RL (n=590) | RN (n=122) | LN (n=9) | 2-sinus (n=73) | P value | RL (n=179) | RN (n=47) | 2-sinus (n=23) | P value | |
| Age, years | 55.5±13.8 | 55.7±13.5 | 51.8±20.2 | 51.3±13.7 | 0.080 | 61.0±11.4 | 59.3±12.6 | 56.0±9.6 | 0.125 |
| BSA, m2 | 2.06±0.19 | 2.05±0.19 | 1.92±0.20 | 2.07±0.20 | 0.136 | 1.82±0.20 | 1.78±0.20 | 1.78±0.15 | 0.434 |
| Hypertension, n (%) | 255 (43.2) | 48 (39.3) | 3 (33.3) | 24 (32.9) | 0.337 | 79 (44.1) | 17 (36.2) | 11 (47.8) | 0.547 |
| Diabetes, n (%; n=583) | 29 (9.3) | 4 (5.4) | 1 (20.0) | 2 (5.9) | 0.400 | 10 (8.8) | 5 (15.6) | 1 (8.3) | 0.492 |
| Dyslipidaemia, n (%) | 72 (12.2) | 17 (13.9) | 3 (33.3) | 8 (11.0) | 0.264 | 22 (12.3) | 6 (12.8) | 5 (21.7) | 0.436 |
| Valve disease | |||||||||
| Aortic valve stenosis, n (%) | 351 (59.5) | 85 (69.7) | 5 (55.6) | 50 (68.5) | 0.104 | 146 (81.6) | 37 (78.7) | 20 (87.0) | 0.742 |
| Aortic valve insufficiency, n (%) | 201 (34.1) | 31 (25.4) | 4 (44.4) | 16 (21.9) | 0.047 | 13 (7.3)* | 10 (21.3)* | 1 (4.3) | 0.017 |
| Dilatation only, n (%) | 38 (6.4) | 6 (4.9) | 0 (0.0) | 7 (9.6) | 0.565 | 20 (11.2)* | 0 (0.0)* | 2 (8.7) | 0.026 |
| Aortic dimensions† | |||||||||
| Annulus, cm | 2.7±0.4 (n=421) | 2.6±0.3 (n=90) | 2.6±0.3 (n=8) | 2.7±0.3 (n=55) | 0.271 | 2.3±0.4 (n=133) | 2.3±0.3 (n=40) | 2.1±0.2 (n=19) | 0.060 |
| Sinus of Valsalva, cm | 3.8±0.6 (n=495)* | 3.6±0.5 (n=101)* | 3.5 ±+0.3 (n=8) | 3.7±0.6 (n=62) | 0.002 | 3.3±0.6 (n=156)* | 3.2±0.5 (n=41) | 2.9±0.5 (n=22)* | 0.024 |
| Sinotubular junction, cm | 3.3±0.6 (n=412)* | 3.1±0.5 (n=87)* | 3.1±0.5 (n=7) | 3.2±0.5 (n=55) | 0.048 | 2.9±0.6 (n=137) | 2.7±0.4 (n=36) | 2.7±0.5 (n=19) | 0.409 |
| Ascending aorta, cm | 4.2±0.9 (n=515) | 4.0±0.7 (n=107) | 3.8±0.7 (n=8) | 4.3±0.7 (n=64) | 0.116 | 4.1±0.8 (n=159) | 3.9±0.8 (n=43) | 3.7±0.8 (n=21) | 0.089 |
| Aortopathy | |||||||||
| Any dilatation, n (%; n=1003) | 222 (39.2) | 33 (28.7) | 1 (11.1) | 28 (39.4) | 0.065 | 52 (30.2) | 9 (20.5) | 5 (21.7) | 0.347 |
| Ascending phenotype, n (%) | 160 (28.2) | 27 (23.5) | 1 (11.1) | 20 (28.2) | 0.569 | 48 (27.9) | 9 (20.5) | 5 (21.7) | 0.536 |
| Root phenotype, n (%) | 13 (2.3) | 0 (0.0)* | 0 (0.0) | 5 (7.0) | 0.031 | 1 (0.6) | 0 (0.0) | 0 (0.0) | 1.000 |
| Root extended, n (%) | 49 (8.6) | 6 (5.2) | 0 (0.0) | 3 (4.2) | 0.433 | 3 (1.7) | 0 (0.0) | 0 (0.0) | 1.000 |
*Groups are significantly different after Bonferroni corrections for multiple comparisons.
†P values adjusted for age and BSA.
BSA, body surface area; LN, left-non-coronary fusion;; RL, right–left fusion; RN, right-non-coronary fusion.