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. 2021 Oct 20;9(10):e003353. doi: 10.1136/jitc-2021-003353

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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All the distinct lymphoid reactions were significantly correlated with HEV density. (A) Three lymphoid reactions—CLR, PLR, and ILR—were evaluated with IHC stain. (B) Representative images of the three distinct lymphoid reactions, which were semiquantitatively scored as 1, 2, and 3. Scale bars: 200 µm. (C) The distribution of 0‒3 scoring of the three lymphoid reactions (CLR, PLR, and ILR) is shown. CLR (D), PLR (E), ILR (F), and overall lymphoid reaction scores (G) were positively correlated with HEV density. ANOVA with Bonferroni post hoc analysis was used (D–G). *P<0.05, **P<0.01, ***P<0.001. ANOVA, analysis of variance; CLR, Crohn-like lymphoid reaction; HEV, high endothelial venule; IHC, immunohistochemistry; ILR, intratumoral lymphoid reaction; PLR, peritumoral lymphoid reaction.