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. 2021 Oct 20;9(10):e003353. doi: 10.1136/jitc-2021-003353

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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HEV density and ILR score were significant prognostic factors for both RFS and OS. (A,B) Kaplan-Meier survival curve according to HEV density showed significant association with RFS (A) and OS (B) (log-rank test p<0.001 and p<0.001, respectively). (C,D) Scoring of CLR was not significantly associated with RFS (C) and OS (D) (log-rank test p=0.991 and p=0.82, respectively). (E,F) Scoring of PLR was not significantly associated with RFS (E) and OS (F) (log-rank test p=0.436 and p=0.352, respectively). (G,H) Scoring of ILR was significantly associated with both RFS (G) and OS (H) (log-rank test p=0.028 and p=0.019, respectively). CLR, Crohn-like lymphoid reaction; HEV, high endothelial venules; ILR, intratumoral lymphoid reaction; OS, overall survival; PLR, peritumoral lymphoid reaction; RFS, relapse-free survival.