Table 1.
Comparison of the clinicopathological factors according to the HEV density
| Parameter | N=452 (%) | Low HEV density | High HEV density | P value |
| n=226 (%) | n=226 (%) | |||
| Sex | 0.010 | |||
| Male | 297 (65.7) | 162 (71.7) | 135 (59.7) | |
| Female | 155 (34.3) | 64 (28.3) | 91 (40.3) | |
| Age (years) | 0.452 | |||
| <58 | 223 (49.3) | 107 (47.3) | 116 (51.3) | |
| ≥58 | 229 (50.7) | 119 (52.7) | 110 (48.7) | |
| Histology | 0.026 | |||
| WD/MD | 172 (38.1) | 98 (43.4) | 74 (32.7) | |
| PD/SRC | 280 (61.9) | 128 (56.6) | 152 (67.3) | |
| Lauren type | 0.019 | |||
| Intestinal | 220 (48.7) | 123 (54.4) | 97 (42.9) | |
| Diffuse | 232 (51.3) | 103 (45.6) | 129 (57.1) | |
| Location | 0.001 | |||
| Upper | 85 (18.8) | 38 (16.8) | 47 (20.8) | |
| Mid | 105 (23.2) | 39 (17.3) | 66 (29.2) | |
| Low | 258 (57.1) | 145 (64.2) | 113 (50.0) | |
| Whole | 4 (0.9) | 4 (1.8) | 0 (0) | |
| T stage | <0.001 | |||
| pT1 | 145 (32.1) | 58 (25.7) | 87 (38.5) | |
| pT2 | 59 (13.1) | 27 (11.9) | 32 (14.2) | |
| pT3 | 103 (22.8) | 48 (21.2) | 55 (24.3) | |
| pT4 | 145 (32.1) | 93 (41.2) | 52 (23.0) | |
| N stage | 0.001 | |||
| pN0 | 202 (44.7) | 81 (35.8) | 121 (53.5) | |
| pN1 | 71 (15.7) | 42 (18.6) | 29 (12.8) | |
| pN2 | 86 (19.0) | 44 (19.5) | 42 (18.6) | |
| pN3 | 93 (20.6) | 59 (26.1) | 34 (15.0) | |
| TNM stage | <0.001 | |||
| I | 139 (30.8) | 57 (25.2) | 82 (36.3) | |
| II | 144 (31.9) | 64 (28.3) | 80 (35.4) | |
| III | 169 (37.4) | 105 (46.5) | 64 (28.3) | |
| Crohn-like lymphoid reaction | <0.001 | |||
| Score 0 | 75 (16.6) | 59 (26.1) | 16 (7.1) | |
| Score 1 | 203 (44.9) | 112 (49.6) | 91 (40.3) | |
| Score 2–3 | 174 (38.5) | 55 (24.3) | 119 (52.7) | |
| Peritumoral lymphoid reaction | 0.163 | |||
| Score 0 | 83 (18.4) | 49 (21.7) | 34 (15.0) | |
| Score 1 | 226 (50.0) | 111 (49.1) | 115 (50.9) | |
| Score 2–3 | 143 (31.6) | 66 (29.2) | 77 (34.1) | |
| Intratumoral lymphoid reaction | 0.016 | |||
| Score 0 | 29 (6.4) | 21 (9.3) | 8 (3.5) | |
| Score 1 | 304 (67.3) | 154 (68.1) | 150 (66.4) | |
| Score 2–3 | 119 (26.3) | 51 (22.6) | 68 (30.1) | |
| Overall lymphoid reaction | <0.001 | |||
| Score 0–2 | 97 (21.5) | 69 (30.5) | 28 (12.4) | |
| Score 3–6 | 313 (69.2) | 147 (65.0) | 166 (73.5) | |
| Score 7–9 | 42 (9.3) | 10 (4.4) | 32 (14.2) |
HEV, high endothelial venule; MD, moderately differentiated; PD, poorly differentiated; SRC, signet ring cell; TNM, tumor, node, metastasis; WD, well differentiated.