Table 3.

Least squares regression slopes for each study included in the pooled log scale regression analysis for temporal trends of IE incidence and the average of individual studies

Studies included	Country	Incidence per 100 k		Log incidence
		Estimated annual increase (per 100 k)	95% CI	Estimated annual increase (%)	95% CI
Shah 202013	Scotland	0.040	0.033 to 0.047	0.54	0.44 to 0.64
Olmos 201717	Spain	0.064	0.050 to 0.078	2.09	1.61 to 2.57
Dayer and Thornhill 2011–20202	England	0.144	0.126 to 0.162	4.23	3.82 to 4.64
Jensen 20204	Denmark	0.312	0.263 to 0.361	4.17	3.50 to 4.84
Fedeli 201126	Italy	0.128	0.052 to 0.204	2.83	1.58 to 4.08
Ahtela 201911	Finland	0.103	0.024 to 0.182	1.66	0.42 to 2.89
van den Brink 201631	Netherlands	0.583	0.470 to 0.696	13.05	10.59 to 15.51
Keller 20163	Germany	0.535	0.387 to 0.683	4.52	1.77 to 6.39
	Average of individual studies	0.239	0.060 to 0.418	4.14	0.90 to 7.37
	Pooled regression	0.238	0.096 to 0.380	4.08	1.77 to 6.39

IE, infective endocarditis.