Table 4.
Univariate and multivariate analysis for OS.
| Variables | Univariate | Multivariate | |
|---|---|---|---|
| P value | HR(95% CI) | P value | |
| Age, years (>50 vs.≤50) | 0.530 | NA | |
| Gender (male vs. female) | 0.879 | NA | |
| HBsAg (positive vs. negative) | 0.373 | NA | |
| AFP, ng/ml (>20 vs. ≤20) | 0.001 | 1.890 (1.120-3.189) | 0.017 |
| Cirrhosis (yes vs. no) | 0.610 | NA | |
| Tumor number (multiple vs. single) | 0.393 | NA | |
| Tumor size, cm (>5 vs. ≤5) | 0.000 | NS | |
| Metastasis (yes vs. no) | 0.030 | NS | |
| Portal vein invasion (present vs. absent) | 0.000 | 2.786 (1.550-5.008) | 0.001 |
| Pretreatment serum LAG-3 (high vs. low) | 0.000 | 2.076 (1.273-3.385) | 0.003 |
| Pretreatment serum PD-L1 (high vs. low) | 0.853 | NA | |
| Baseline bilirubin (high vs. low) | 0.716 | NA | |
| Baseline ALT (high vs. low) | 0.066 | NA | |
| Baseline AST (high vs. low) | 0.001 | NS | |
OS, overall survival; DFS, disease-free survival; HBsAg, hepatitis B surface antigen; AFP, αfetoprotein; HR, hazard ratio; CI, confidential interval; NA, not adopted; NS, not significant. P < 0.05 was considered as statistically significant.