Additional Table 3.

LA severity is associated with 1-year stroke recurrence in univariate Cox regression analysis

	HR (95%CI)	P value
Age	1.034 (1.009-1.059)	0.007
Male	1.803 (0.990-3.282)	0.054
Drinking	0.730 (0.350-1.521)	0.401
Smoking	0.970 (0.512-1.835)	0.925
Hypertension	0.812 (0.376-1.754)	0.596
Diabetes mellitus	1.792 (0.859-3.736)	0.120
Prior stroke	0.646 (0.273-1.531)	0.321
Atrial fibrillation	1.512 (0.468-4.888)	0.490
Antiplatelet use	0.633 (0.226-1.771)	0.384
Statins use	0.960 (0.297-3.104)	0.946
Admission SBP	0.995 (0.983-1.008)	0.475
Admission DBP	0.982 (0.961-1.004)	0.101
Admission MAP	0.987 (0.968-1.006)	0.178
Admission Glucose	1.035 (0.920-1.166)	0.566
Admission Cholesterol	1.016 (0.769-1.344)	0.910
Admission TG	1.182 (0.985-1.420)	0.072
Admission LDL	0.961 (0.687-1.344)	0.815
Admission HDL	1.054 (0.740-1.502)	0.770
Admission BUN	1.044 (0.980-1.112)	0.178
Admission Cr	1.001 (0.998-1.003)	0.530
Hematoma volume	1.018 (0.990-1.047)	0.205
Hematoma location (lobar/non-lobar)	0.969 (0.478-1.969)	0.931
SBI	3.039 (1.623-5.692)	<0.001
CMBs	1.026 (0.990-1.063)	0.159
LA severity	1.195 (1.036-1.378)	0.014

LA severity was entered as an ordinal categorical variable (no vs. mild vs. moderate vs. severe). Stroke recurrence was defined as readmission to hospital with a definite diagnosis of stroke. BUN: blood urea nitrogen; CMBs: cerebral microbleeds; Cr: creatinine; DBP: diastolic blood pressure; HDL: high density lipoprotein; LA: leukoaraiosis; LDL: low density lipoprotein; MAP: mean arterial pressure; SBI: silent brain infarction; SBP: systolic blood pressure; TG: triglyceride.