Figure 2.

Activated microglia contribute to learning and memory deficits in different disorders.

Active microglia can disrupt neuronal plasticity and cognitive function in different neurological and mental disorders, and these deficits can be ameliorated by microglia depletion or drugs targeting microglia signaling pathways. AD: Alzheimer’s disease; C1q: complement component 1q; DDX3: Dead-box RNA helicase 3; GC: glucocorticoids; HAND: HIV-associated neurocognitive disorder; IL-10: interleukin 10; IL-33: interleukin 33; miR-233: microRNA-233; NLRP3: NOD-like receptor protein 3; TBI: traumatic brain injury; TREM2: triggering receptor expressed on myeloid cells 2.