Table 1.
Comparisons of demographic and clinical features of ALS patients among the three subgroups according to NLR
| Variables | Total | NLR on admission | P-value | ||
|---|---|---|---|---|---|
|
| |||||
| < 2 | 2–3 | > 3 | |||
| n | 1030 | 544 (52.8) | 314 (30.5) | 172 (16.7) | |
| Age (yr)a | 57.0±11.4 | 56.2±11.3 | 56.9±11.0 | 59.5±12.0 | 0.004 |
| Sex (male)b | 58.8 | 53.7 | 65.3 | 63.4 | 0.002 |
| Body mass index | |||||
| (kg/m2)a | 21.8±3.0 | 21.7±2.9 | 22.2±3.1 | 21.7±3.1 | 0.059 |
| Onset age (yr)a | 55.6±11.4 | 54.8±11.4 | 55.5±11.0 | 58.1±12.0 | 0.004 |
| Onset region | |||||
| (bulbar)b | 22.6 | 25.4 | 17.8 | 22.7 | 0.04 |
| Diagnostic duration (mon)a | 16.5±16.4 | 16.7±18.3 | 16.2±12.9 | 16.6±15.6 | 0.918 |
| Diagnostic delay (mon)a | 15.0±13.8 | 15.3±15.1 | 14.7±12.4 | 15.1±14.3 | 0.84 |
| ALSFRS-Ra | 38.6±6.4 | 39.4±5.6 | 38.6±6.4 | 35.9±7.9 | < 0.001 |
| Disease progression ratea | 0.84±0.76 | 0.77±0.65 | 0.80±0.71 | 1.12±1.06 | < 0.001 |
| Classical phenotypeb | 64.3 | 61.4 | 69.7 | 63.4 | 0.047 |
| Early stageb | 64.4 | 67.6 | 65.6 | 51.7 | 0.001 |
Data are presented as the mean ± SD (a) or percentage (b) and were analyzed by one-way analysis of variance (age, body mass index, onset age, diagnostic duration, diagnostic delay, ALSFRS-R, disease progression rate) or chi-squared test (sex, onset region, classical phenotype, early stage). ALS: Amyotrophic lateral sclerosis; ALSFRS-R: Revised Amyotrophic Lateral Sclerosis Functional Rating Scale; NLR: neutrophil-to-lymphocyte ratio.