Figure 6.

MEG3 knockdown ameliorates CI/RI-induced behavioral deficits.

Si-MEG3 or si-NC was injected into the right ventricle of the mice, and then MCAO was performed for 1 hour, followed by reperfusion. (A) The TLT in the elevated plus maze test was measured immediately and 4 days after reperfusion. (B) The motor ability score in the inclined beam-walking test was determined at 0, 12, and 24 hours after reperfusion. (C) The lateral push resistance in the lateral push test was evaluated at 0, 12, and 24 hours after reperfusion. Data are expressed as mean ± SD (n = 4). ††P < 0.01, vs. MCAO group (one-way analysis of variance followed by the least significant difference post hoc test). CI/RI: Cerebral ischemia-reperfusion injury; MCAO: middle cerebral artery occlusion; MEG3: maternally expressed gene 3; TLT: transfer latency time.