. Author manuscript; available in PMC: 2021 Oct 21.

Published in final edited form as: Pediatr Radiol. 2019 Jan 3;49(3):332–341. doi: 10.1007/s00247-018-4319-1

Table 4.

Diagnostic performance of MRI and laboratory-based biomarkers for indicating presence of radiologic portal hypertension

	AUROC	95% CI	P-value	Cut-offvalue	Sensitivity	Specificity
Liver stiffness (kPa)	0.98	0.95–1.00	<0.0001	>3.9	92.3%	93.6%
Spleen stiffness (kPa)	0.96	0.89–1.00	<0.0001	>7.3	90.9%	93.3%
Liver cT1 (ms)	0.86	0.75–0.97	0.0003	>1,001.3	84.6%	75.9%
Liver T2 (ms)	0.63	0.44–0.81	0.19	>60.0	76.9%	51.6%
Liver ADC (×10⁻³mm²/s)	0.55	0.35–0.75	0.61	<1.18	53.8%	64.5%
APRI score	0.87	0.76–1.00	0.0002	>0.66	91.7%	80.0%
FIB-4 score	0.88	0.75–1.00	<0.0001	>0.76	84.6%	93.3%

ADC apparent diffusion coefficient, APRI aspartate aminotransferase (AST)-to-platelet ratio index, AUROC area under the receiver operating characteristic curve, CI confidence interval, cT1 iron-corrected T1, FIB-4 fibrosis-4