Table 2.

Adjusted 6- and 12-month Changes in Imaging Biomarkers.

Measure	Cycling		Stretching		Between-group difference
	Mean (SD)	p (from baseline)	Mean (SD)	p (from baseline)	p
6-month changes
Hippocampal volume	−0.139 (0.198)	0.001*	−0.155 (0.142)	0.001*	0.759
Temporal meta–ROI cortical thickness	−0.024 (0.040)	0.002*	−0.039 (0.047)	0.001*	0.156
WMH volume	1534 (2270)	0.001*	3381 (3612)	0.001*	0.030*
NFQ	0.029 (0.258)	0.531	0.038 (0.247)	0.517	0.687
12-month changes
Hippocampal volume	−0.227 (0.185)	0.001*	−0.201 (0.142)	0.001*	0.886
Temporal meta-ROI cortical thickness	−0.057 (0.057)	0.001*	−0.045 (0.053)	0.002*	0.936
WMH volume	1829 (2185)	0.001*	3764 (3348)	0.001*	0.015*
NFQ	−0.057 (0.266)	0.285	0.079 (0.357)	0.377	0.174

^*p < 0.05.