TABLE 3.
Specimens tested and results obtained with three HBsAg screening assays
| Specimen collection or type | No. of samples positive/no. of samples tested with:
|
||
|---|---|---|---|
| Elecsys HBsAg | Auszyme Monoclonal B | IMx HBsAg | |
| HBsAg sensitivity panel PHA 805 | 18/20 | 15/20 | 16/20 |
| Abbott sensitivity panel | 13/20 | 11/20 | |
| HBsAg mixed-titer panel PHA 202 | 23/25 | 23/25 | 23/25 |
| HBsAg mixed-titer panel PHA 203 | 23/25 | 23/25 | 23/25 |
| HBsAg low-titer panel PHA 102 | 14/15 | 14/15 | 11/15 |
| HBsAg low-titer panel PHA 103 | 14/15 | 14/15 | 12/15 |
| LNS panel | 10/10 | 10/10 | |
| Seroconversion panels | 94/184 | 79/184 | 73/184 |
| Acute hepatitis B | 20/20 | 20/20 | 20/20 |
| Chronic hepatitis B | 170/170 | 169/170 | |
| HBsAg- and anti-HBc-IgM-positive sera | 46/46 | 46/46 | |
| HBsAg-, HBeAg-, and antiHBc-positive sera | 27/27 | 27/27 | |
| HBsAg-positive sera | 179/179 | 179/179 | |
| Isolated anti-HBc-positive samples | 4/147 | 0/147 | |
| HBsAg-negative South African blood donor samples | 1/490 | 1/490 | 5/490 |
| Potentially cross-reactive seraa | 6/444 | 5/444 | |
| Potentially cross-reactive serab | 42/1,470 | 88/1,470 | |
a
Rheumatoid factor-positive sera; serum samples from anti-HBV-vaccinated individuals, dialysis patients, and hemophiliacs; and sera from patients suffering from alcohol-related liver disease, acute or chronic viral and bacterial infections, and autoimmune diseases.
b
Serum samples from IVDAs, homosexuals, and pregnant women and specimens from hospitalized patients who were treated for cancer, nephropathy, and gastroenterologic symptoms.