Table 1. Mouse models and diet.
Mice | Surgery Age* | Diet** | Surgery |
---|---|---|---|
BKS-db/db | 6w | Chow | RYGB or Sham-PF*** |
NZO | 6w | HFD | RYGB or Sham-PF |
STZ | 10w | Chow | RYGB or Sham-PF |
B6-db/db | 6w | Chow | RYGB or Sham-PF |
*: BKS-db/db, B6-db/db and NZO mice underwent RYGB or sham surgery at 6 weeks of age, and streptozotocin (STZ)-induced diabetic mice underwent RYGB or sham surgery at 10 weeks of age.
**: BKS-db/db, B6-db/db and STZ mice were fed with chow for whole study period. NZO mice were fed with chow up to 6 weeks of age and underwent RYGB or sham surgery followed by high-fat diet (HFD, 60% fat, Bio-Serv) feeding up to the endpoint.
***: Sham-PF, mice undergo sham surgery with pair feeding. The amount of diet provided to the mouse with sham surgery is matched to that consumed by the mouse with RYGB.