Fig 7. Prophylactic efficacy of mouse monoclonal neutralizing antibody cocktail against SARAS-CoV-2 infection in hamsters.

A. Illustration of the study design for prophylactic efficacy of monoclonal mouse antibodies, against SARS-CoV-2 in hamster. Three or five days prior to intranasal challenge of SARS-CoV-2, each group of hamster was given a single intraperitoneal dose of 1.5 mg/kg of RBD-mAb-25 (n = 3), RBD-mAb-45 (n = 3), or 3 mg/kg of RBD-mAb-25 combined RBD-mAb-45 (n = 4), 3 mg/kg of NMIgG as isotype control (n = 4). On day 3 after virus inoculation, body weights were recorded and lung samples were collected for analysis. B. The percentage of body weight were compare to the body weight in the day of virus inoculation. C. The viral load in the lung was determined by qRT-PCR. D. The infectious viral load in the lung was determined by median tissue culture infectious dose per ml (TCID₅₀/ml) was calculated. Data information: All data points are shown, along with the median. *** p < 0.001, as determined by Student’s t-test. ctrl, isotype control. i.p., intraperitoneal. LOD, limit of detection, 1 × 10² TCID₅₀/ml.