Fig. 1.

Experimental timeline. Methyazoxymethanol acetate (MAM) and SAL rats received peripubertal treatments (PD 31–40) and cohorts were randomly split into groups that were either tested during late adolescence (PD 47–56) or adulthood (PD 83–96). A random subset of each group was used for novel object recognition test during the dark cycle, which occurred either PD 47–48 or PD 83–84. Rats were then used for in vivo electrophysiological recordings to record either DA neuron activity in the ventral tegmental area (VTA) or pyramidal neuron activity in the hippocampus.