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. 2021 Apr 30;47(6):1806–1814. doi: 10.1093/schbul/sbab047

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Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center 2021.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Fig. 3. — Reduced novel object recognition only in adult methyazoxymethanol acetate (MAM) rats that did not receive peripubertal injections. (A) In late adolescence (PD 47–48), MAM and SAL rats displayed no differences in time interacting with a novel object compared to a familiar object as measured by a discrimination index ((novel-familiar)/(novel+familiar)) or in locomotor activity as measured by total time spent exploring objects (B). (C) In rats tested in adulthood (PD 83–84), POM-treated MAM rats displayed an increase in time spent exploring the novel object as measured by the discrimination index compared to no injection (NI)-treated MAM rats, though not significantly reduced compared to vehicle-treated MAM rats. (D) No significant differences were observed in total time spent exploring the objects. For all graphs, the numbers in bars represent the number of rats per group. **P < .01 within groups ##P < .01 between groups.