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. 2021 Apr 30;47(6):1806–1814. doi: 10.1093/schbul/sbab047

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Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center 2021.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Fig. 4. — Peripubertal pomaglumetad treatment prevents increased firing rate of ventral hippocampal pyramidal neurons in adult methyazoxymethanol acetate (MAM) rats. (A) In late adolescence (PD 47–56), MAM rats that received vehicle or no injection (NI) during puberty displayed increased firing rate of pyramidal neurons compared to pyramidal neuron firing rate in SAL rats, which was normalized in MAM rats that received peripubertal POM. (B) MAM rats that did not receive injections showed an increase in percentage of spikes in bursts in late adolescence, compared to POM-treated MAM rats. (C) Vehicle and NI-MAM rats recorded in adulthood (PD 83–96) also displayed increased vHPC pyramidal neuron firing rate compared to vehicle and NI-SAL rats. MAM rats that received peripubertal POM had an average pyramidal neuron firing rate not significantly different from SAL rats. (D) No significant differences were observed in the percentage of spikes in burst in vHPC pyramidal neurons recorded in MAM and SAL rats at adulthood. For all graphs, the numbers outside of parenthesis represent the number of neurons per group and the number in parenthesis represents the number of rats per group. *P < .05; **P < .01 within groups ##P < .01 ###P < .001 between groups.