Table 1.
Stress CMR studies with ≥100 patients and comparison to invasive catheterization or patient-related outcomes.
| Review of Stress CMR Publications | |||||
|---|---|---|---|---|---|
| Comparison of Stress CMR Against Invasive ICA | |||||
| Study/Ye ar |
Study size (n) |
Inclusion criteria |
Ref CAD definition |
Sensitivity/ Specificity/AUC |
Results |
| (8)MR-IMPACT (2008) | 241 | Clinical indication for ischemic evaluation | ≥50% diameter stenosis in >1 coronary artery | 85% / 67% / 0.86 | CMR performance similar to SPECT in matched patients (n=42); better performance when comparing CMR with 0.1mmol/kg dose to whole SPECT population (n=212) |
| (9,57)MR - IMPACT II (2012, 2013) | 533 | Suspected CAD/clinical indication for ICA or SPECT | ≥50% diameter stenosis in >1 coronary artery | 75% /59% / 0.75 | CMR diagnostic performance superior to SPECT |
| (7)CE-MARC (2012) | 752 | Suspected angina + 1 cardiovasc ular risk factor | ≥70% area stenosis in ≥1 coronary artery or ≥50% Left main | 87% /83% / AUC 0.89 | CMR has high diagnostic accuracy over SPECT, with greater sensitivity and NPV compared to SPECT |
| Comparison of Stress CMR Against Invasive Fractional Flow Reserve (FFR) | |||||
| (11)Watkins et al (2009) | 103 | Suspected angina with indication for CA | FFR<0.75, or subtotal/total coronary occlusionm | 95%/91% | CMR has high diagnostic accuracy in the detection of functionally significant CAD when compared against FFR reference standard |
| (58)Manka et al (2012) | 120 | Known or suspected CAD | FFR <0.75 in vessels >2mm and >40% stenosis | 90% /82% | 3D stress CMR has high diagnostic accuracy for detection of functionally significant CAD and can represent myocardial ischemic burden accurately |
| (59)Bettencourt et al (2013) | 103 | Symptoma tic patients with suspected CAD or intermedia te-high probability of CAD | FFR <0.80 for any stenosis >40%, or subtotal/occluded vessel | 89% /88% | CMR has high accuracy in detection of functionally significant CAD in intermediate-high pretest probability patients |
| (60)Ebers berger et al (2013) | 116 | Known or Suspected CAD | FFR ≤0.8 OR stenosis >75% | 85% /87%/ 0.93 | 3T stress CMR has excellent diagnostic performance with high image quality |