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. Author manuscript; available in PMC: 2021 Oct 21.
Published in final edited form as: Nat Neurosci. 2021 Apr 12;24(6):810–817. doi: 10.1038/s41593-021-00832-6

Figure 2:

Figure 2:

Protein-protein interaction (PPI) network and pathways among the 25 potentially causal proteins in depression from the meta-analysis of the discovery and replication PWAS of depression. The lines represent physical PPI. The thickness of the lines is proportional to the evidence for the PPI. Community 1 includes CTNND1, CSE1L, SLC25A12, and PSMB4. Community 2 includes LYRM4 and GMPPB. Enrichment of pathways was determined using a hypergenometric test with bonforroni adjustment for for multiple testing correction.