Table 3.
Quantitative analysis of zidovudine from microparticles MB1 and MB2 and control (pure zidovudine dispersed in HEC/SVF, pH 4.2) in acceptor medium, retained in human vaginal epithelium and on the tissue’s surface (drug recovery from donor compartment) after 24 h incubation (mean ± S.D.; n = 4).
| Control |
MB1 |
MB2 |
|||||
|---|---|---|---|---|---|---|---|
| Compartment | Parameter | After 8 h | After 24 h | After 8 h | After 24 h | After 8 h | After 24 h |
| Acceptor medium | Total amount of permeated drug per tissue’s area (μg/cm2) | ||||||
| 109.9 ± 14.9 | 150.6 ± 9.2 | 77.8 ± 17.5 | 112.3 ± 10.1 | 96.3 ± 20.3 | 133.3 ± 9.1 | ||
| Tissue’s retentionb | Total amount of drug per tissue’s area (μg/cm2)a | 6.7 ± 0.6 | 19.6 ± 1.5 | 13.1 ± 0.7 | |||
| Drug recovery from donor compartmentc | Percent of drug dose (%) | 94.0 ± 1.9 | 95.1 ± 2.2 | 91.2 ± 1.0 | |||
a
Dispersion of microparticles-loaded ZVD (MB1–MB2) or ZVD in HEC/SVF (which amount corresponded to dose 5 mg) was placed on the tissue surface with an area of 0.81 cm2; concentrations of ZVD were determined in: bsolvent used for tissue extraction and cdrug dispersion aspirated from the surface of the tissue.