Figure 2.

Modifiers for histone acetylation and methylation. Histone acetylation and deacetylation are catalyzed by HATs and HDACs, respectively. Extensive studies of HATs and HDACs have emphasized the crucial role of histone acetylation and deacetylation in bridging epigenetic, transcriptional, and signaling phenomena to metabolism in obesity. Histone methylations are dynamically regulated by HMTs and HDMs. Histone methylation occurs on basic residues lysine and arginine and confers active or inhibitory transcription, depending on their location and methylation status. Red color indicates the modifiers participated in energy metabolism.