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. Author manuscript; available in PMC: 2021 Oct 21.
Published in final edited form as: Chem Rev. 2009 Apr;109(4):1561–1574. doi: 10.1021/cr800544v

Figure 3. Organization of the HMG-CoA reductase protein.

Figure 3

The integral ER membrane protein HMGR in both mammals and yeast consists of an 8-spanning N-terminal membrane anchor, embedded in the ER membrane (grey) as shown, attached by a linker to the highly conserved catalytic domain that performs the essential enzyme action. Regulated degradation requires the N-terminal transmembrane domain. This region has the conserved sterol-sensing domain (SSD) motif distributed between spans 2 to 5, as discussed in the text.