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. Author manuscript; available in PMC: 2021 Oct 21.
Published in final edited form as: Chem Rev. 2009 Apr;109(4):1561–1574. doi: 10.1021/cr800544v

Figure 6. The structural transition model for Hmg2p regulation.

Figure 6

Regulated degradation of Hmg2p is posited to occur by a regulated change in structure to one that is more susceptible to HRD pathway degradation. Three ways of altering the stability of Hmg2p are indicated, with the direction of arrow showing the effect of each item. The FPP-derived signal causes more degradation, and it thought to altere the structure to one with more features of a misfolded protein. Conversely, Nsg1p or glycerol (a chemical chaperone) both effectively stabilize Hmg2p. Similarly, lowering the FPP-derived signal causes improved folding and thus, increased stability. The lower panel shows the metabolic reaction that generates GGPP from FPP by addition of 5 carbons from IPP, as shown. This reaction is catalyzed by the BTS1 gene product.