Table 1.
Simulated effect of a decrease or increase in chosen parameter values by 10% in relation to “standard” (100%) values on selected variables
| Parameter | Relative Parameter Value | V̇O2max, mM·min−1 | AUTcrit, unitless | t0.63, s |
|---|---|---|---|---|
| kOX | −10% | 11.9 (–10.2%) | 67.1 (–10.2%) | 26.5 (+8.2%) |
| 100% | 13.3 | 74.7 | 24.5 | |
| +10% | 14.7(+10.5%) | 83.3 (+10.5%) | 22.8 (–6.9%) | |
| AOXmax | −10% | 12.2 (–8.4%) | 69.4 (–7.1%) | 26.8(+9.4%) |
| 100% | 13.3 | 74.7 | 24.5 | |
| 10% | 14.4 (+8.6%) | 81.0 (+8.4%) | 22.5 (–8.2%) | |
| Pipeak | −10% | 11.1 (–16.2%) | 66.6 (–10.8%) | 24.5 (--) |
| 100% | 13.3 | 74.7 | 24.5 | |
| +10% | 15.7 (+18.1%) | 84.5 (+13.1%) | 24.5 (--) | |
| Picrit | −10% | 13.3 (--) | 71.5 (–4.3%) | 24.5 (--) |
| 100% | 13.3 | 74.7 | 24.5 | |
| +10% | 13.3 (--) | 78.7 (+5.4%) | 24.5 (--) | |
| kadd | −10% | 13.3 (--) | 72.1 (–3.5%) | 24.5 (--) |
| 100% | 13.3 | 74.7 | 24.5 | |
| +10% | 13.3 (--) | 77.5(+3.7%) | 24.5 (--) |
t0.63 was simulated for ATP usage activity AUT = 40 (moderate exercise). AOXmax, each-step activation (ESA) intensity; AUTcrit, critical ATP usage activity (corresponding to critical power); kadd, activity (rate constant) of the additional ATP usage; kOX, oxidative phosphorylation (OXPHOS) activity; Picrit, critical Pi at which the additional ATP usage (and thus the slow component of the V̇O2 and metabolites) appears; Pipeak, peak Pi at which exercise is terminated because of exercise intolerance; V̇O2max, maximal V̇O2; t0.63, characteristic transition time of the V̇O2 on-kinetics (analogous to τp).